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Prilosec issues
I can't speak to the specific kidney issues, but my doctor ordered me on Omeprazole (Generic Prilosec) a few years ago. After taking it for almost two years, I became uncomfortable with what I've read regarding potential side effects from long term exposure to it. I researched alternatives and have had tremendous success with Betaine HCL, which is an over the counter form of hydrochloric acid. The theory is that heartburn is actually a product of decreased stomach acid, and as we age we produce less acid.

I was originally diagnosed with Barrett's esophagus. Taking that supplement a couple times a day has wiped out any heartburn I was having. I'm due for a physical this week, and we will see if the condition has improved as I think it has.
I also have Barrett's esophagus and was on both Omeprazole and Pantoprazole but not as effective as hoped, GERD surgery’s the next step and I was recently involved in a liver study where Betaine was taken, it took care of the liver numbers but did nothing for the acid attacks.
Serious side effects of Prilosec (omeprazole) may include:
Kidney injury, damage or failure.
Acute Interstitial Nephritis (AIN)
Bone fracture of the hip, wrist or spine.
Vitamin B-12 deficiency.
Clostridium difficile-associated diarrhea (caused by intestinal infection)
Lupus Erythematosus.
Low magnesium levels.

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