Workers' Compensation Discussion Forums

It's my opinion that BMP's could work well, if the correct BMP is used, as there are many types of BMP's....

BMP Known functions Gene Locus
BMP1 *BMP1 does not belong to the TGF-β family of proteins. It is a metalloprotease that acts on procollagen I, II, and III. It is involved in cartilage development. Chromosome: 8;

BMP2 Acts as a disulfide-linked homodimer and induces bone and cartilage formation. It is a candidate as a retinoid mediator. Plays a key role in osteoblast differentiation. Chromosome: 20;

BMP3 Induces bone formation Chromosome: 14;

BMP4 Regulates the formation of teeth, limbs and bone from mesoderm. It also plays a role in fracture repair. Chromosome: 14;

BMP5 Performs functions in cartilage development. Chromosome: 6;

BMP6 Plays a role in joint integrity in adults. Chromosome: 6;

BMP7 Plays a key role in osteoblast differentiation. It also induces the production of SMAD1. Also key in renal development and repair. Chromosome: 20;

BMP8a Involved in bone and cartilage development Chromosome: 1;

BMP8b Expressed in the hippocampus. Chromosome: 1;

BMP10 May play a role in the trabeculation of the embryonic heart. Chromosome: 2;

BMP15 May play a role in oocyte and follicular development. Chromosome: X;

BMPs are now produced using recombinant DNA technology. These formulations have found applications[citation needed] in many disciplines of medicine and dentistry. Orthopaedic medicine and oral surgery have benefited[citation needed] greatly from commercially available BMP formualtions in the last few years.

BMPs are also available in an oral form under the commercial name Ostinol™. It is being marketed as a supplement for bone and joint health[citation needed] by Holistic and alternative health care practitioners.

BMPs interact with specific receptors on the cell surface, referred to as bone morphogenetic protein receptors (BMPRs).

Signal transduction through BMPRs results in mobilization of members of the SMAD family of proteins. The signaling pathways involving BMPs, BMPRs and Smads are important in the development of the heart, central nervous system, and cartilage, as well as post-natal bone development.

They have an important role during embryonic development on the embryonic patterning and early skeletal formation. As such, disruption of BMP signaling can affect the body plan of the developing embryo. For example, BMP4 and its inhibitors noggin and chordin help regulate polarity of the embryo (i.e. back to front patterning).

Mutations in BMPs and their inhibitors (such as sclerostin) are associated with a number of human disorders which affect the skeleton.

Several BMPs are also named 'cartilage-derived morphogenetic proteins' (CDMPs), while others are referred to as 'growth differentiation factors' (GDFs).

Spinal Fusion surgery itself raises costs and increases mortality and complication rates in back pain patients let alone increases disability with very little , as in very limited indications, to perform the surgery in the first place.

Limbo,
Do you know what their reasons were for FDA pulling the Adocon L other than they did like like the way the studies were done? I am interested in knowing more about this issue if you have any info. I am also confused and don't always understand some of what I read. Do this have any relation to the use of Donor Bones instead of using your own bone? Sometimes I don't grab the medical terminology or the aspect of the message. When they did my cervical fusions I used Donor Bones from a bone bank instead of my own. My doctor stated the recovery from the surgery was alot easier than taking the bone from the hip because people have to much pain and trouble being able to walk sooner from the removable of your own bone. For your sake since the Adocone L worked so well for you I am saddened to hear they have pulled this. I know how much trouble and suffering you have from scar tissue. God Bless and Love ya!

Cajun Hugsssssssssss,
MJC